Until recently, no uniform standard existed for diagnosing and classifying acute renal failure. To clarify diagnosis,the Acute Dialysis Quality Initiative group stated its consensus on the need for a clear definition and classification system of renal dysfunction with measurable criteria.Today the term acute kidney injury has replaced the term acute renal failure,with an understanding thatsuch injury is a common clinical problemin critically ill patients and typically is predictive of an increase in morbidity andmortality.Aclassification system, known asRIFLE (risk of injury, injury,failure, loss offunction, and end-stagerenalfailure), includesspecific goalsfor preventing acute kidney injury: adequate hydration,maintenance ofrenal perfusion, limiting exposureto nephrotoxins, drug protectivestrategies, and the use ofrenal replacementtherapiesthatreducerenalinjury.
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